Oligooxopiperazines as Nonpeptidic α-Helix Mimetics
ORGANIC LETTERS（2010）
摘要
A new class of nonpeptidic alpha-helix mimetics derived from alpha-amino acids and featuring chiral backbones Is described. NMR and circular dichroism spectroscopies, In combination with molecular modeling studies, provide compelling evidence that oligooxopiperazine dimers adopt stable conformations that reproduce the arrangement of i, i+4, and i+7 residues on an alpha-helix.
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