Synthetic investigations of rapamycin. 1. Synthesis of a C10-C21 fragment

Stephanie D. Meyer,Tetsuo Miwa,Masashi Nakatsuka,Stuart L. Schreiber

JOURNAL OF ORGANIC CHEMISTRY（1992）

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摘要

Phosphine oxide 2, representing the C-10-C21 portion of rapamycin, was stereoselectively synthesized and was demonstrated to undergo a Homer-Wittig reaction to form triene 25 as an 8:1 mixture of trans-cis isomers.

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