高效液相色谱法测定胞磷胆碱钠注射液中的有关物质
Pharmaceutical Journal of Chinese People's Liberation Army(2011)
Abstract
目的建立胞磷胆碱钠注射液中有关物质的高效液相色谱测定方法。方法采用C18柱(250 mm×4.6 mm,5μm),以磷酸盐缓冲液(0.1 mol/L磷酸二氢钾与0.01 mol/L四丁基氢氧化铵等量混合,用磷酸调节pH值至5.2)-甲醇(96∶4)为流动相,流速:0.8 ml/min,检测波长:276 nm,柱温:30℃。结果经破坏性试验后的胞磷胆碱钠注射液中各有关物质与胞磷胆碱分离良好;最低检测限为0.006 ng。结论该方法简便、专属性及灵敏度好,可用于胞磷胆碱钠注射液中有关物质的检查。
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Key words
related substances,citicoline sodium,high performance liquid chromatography
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