Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: tuning of receptor selectivity and in vivo efficacy.

Marna Pippel,Kristen Boyce,Hariharan Venkatesan,Victor K Phuong,Wen Yan,Terrance D Barrett,Guy Lagaud,Lina Li,Magda F Morton,Clodagh Prendergast,Xiaodong Wu,Nigel P Shankley,Michael H Rabinowitz

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

Optimization of affinity for both CCK1 and CCK2 receptors results in compounds that both inhibit pancreatic enzyme secretion and inhibit the production of gastric acid in animal models.

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关键词

CCK receptor antagonist

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