Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives.

Xiaolu Jiang,Lu Zhou,Dengguo Wei,Hu Meng,Ying Liu,Luhua Lai

Bioorganic & Medicinal Chemistry Letters（2008）

引用 30|浏览33

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摘要

Diphenyl ether and derivatives can either activate or inhibit the aminopeptidase activity of leukotriene A4 hydrolase, by binding at the hydrophobic pocket of LTA4H.

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关键词

Leukotriene A4 hydrolase/aminopeptidase,Diphenyl ether derivatives,Activators,Inhibitors

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