A High Relaxivity Magnetic Resonance Imaging Contrast Agent Targeted to Serum Albumin

Stéphane Dumas,Jeffrey S. Troughton,Normand J. Cloutier,Jaclyn M. Chasse,Thomas J. McMurry,Peter Caravan

AUSTRALIAN JOURNAL OF CHEMISTRY（2008）

引用 14|浏览11

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摘要

EP-647 is a serumalbumin-targeted magnetic resonance imaging contrast agent comprising a GdDTPA( DTPA, diethylenetriaminepentaacetate) chelate for magnetic resonance signal generation linked via a phosphodiester to a substituted biphenyl for albumin targeting. Albumin binding and relaxivity are higher than the benchmark magnetic resonance angiographic agent MS-325. EP-647 binds primarily to a unique site on serum albumin that is different from the MS-325 site and the binding sites of other drugs.

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关键词

nanotechnology,proteins,biological chemistry,structure,serum albumin,organic chemistry,analytical chemistry,biosensors,computational chemistry,crystallography,polymer chemistry,kinetics,biocatalysis,magnetic resonance image,enzymes,medicinal chemistry,photochemistry,ab initio calculations,combinatorial,educational,electrochemistry,mass spectrometry,inorganic chemistry,reaction mechanisms,catalysis,self assembly,sensors,amino acids,colloids,interfaces,supramolecular chemistry,crystal structures,ionic liquids,pharmaceutical chemistry,peptide,spectroscopy,surface chemistry,density functional theory,quantum chemistry,physical chemistry,combinatorial chemistry,green chemistry,macromolecules

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