Scavenging of long-lived radicals by (−)-epigallocatechin-3-O-gallate and simultaneous suppression of mutation in irradiated mammalian cells
Radiation Physics and Chemistry(2002)
摘要
Effect of (−)-epigallocatechin-3-O-gallate (EGCg) on scavenging long-lived radicals and its biological significance were investigated using electron-spin-resonance spectroscopy and mutation assay in cultured human embryo cells. EGCg scavenged long-lived radicals in irradiated golden hamster embryo cells and albumin solution, and simultaneously reduced mutation frequency in the irradiated human embryo cells. These results indicate that long-lived radials are involved in the induction of mutation by radiation.
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关键词
Long-lived radicals,(−)-Epigallocatechin-3-O-gallate,Mutation,Mammalian cells,Electron spin resonance
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