Time efficient detection of protein–ligand interactions with the polarization optimized PO-WaterLOGSY NMR experiment

Journal of Biomolecular Nmr, Volume 43, Issue 4, 2009, Pages 211-217.

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Abstract:

The identification of compounds that bind to a protein of interest is of central importance in contemporary drug research. For screening of compound libraries, NMR techniques are widely used, in particular the Water-Ligand Observed via Gradient SpectroscopY (WaterLOGSY) experiment. Here we present an optimized experiment, the polarizati...More

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