S1021 Prevalence and Predictors of Fecal Occult Blood Testing after Colonoscopy

transfected with RET-PTC2 readily differentiated and assumed a configuration that resembled plexoid bodies.The expression of PGP9.5 and GFAP were increased (2.6 and 2.4 folds respectively by qRT-PCR and 1.6 and 1.4 folds respectively by Western blotting) as compared to control cells transfected with RET-PTC2 and cultured without LMMP.Additionally, the expression of nNOS was increased (3.3 folds by qRT-PCR).Conclusions Our data show that activation of the GDNF receptor RET specifically direct CNS-NSC to acquire an enteric neuronal phenotype.Additionally, gut-derived factors are responsible for driving glial differentiation and the formation of ganglionated plexi.By establishing a permissive and necessary role of RET, these results provide further and critical groundwork for the therapeutic use of neuronal precursors in the gut.