Discovery of a novel series of Notch-sparing γ-secretase inhibitors

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

Lead optimization studies of Notch-sparing GSI 2a led to the discovery of analog 8e with improved γ-secretase inhibitory potency and Notch-sparing selectivity.

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关键词

Alzheimer’s disease,γ-Secretase,Notch,Amyloid,Protease inhibitor

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