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Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode

M. Raymond V. Finlay,David G. Acton,David M. Andrews,Andrew J. Barker,Michael Dennis,Eric Fisher,Mark A. Graham,Clive P. Green,David W. Heaton,Galith Karoutchi,Sarah A. Loddick,Rémy Morgentin,Andrew Roberts,Julie A. Tucker,Hazel M. Weir

Bioorganic & Medicinal Chemistry Letters（2008）

引用 37|浏览58

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摘要

A series of CDK inhibitors with a novel binding mode and good activity in clinically relevant disease models is reported.

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关键词

CDK,Kinase,Inhibitor,Cancer

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