Synthesis and renal vasodilator activity of substituted [4-alkyl(aryl)quinazolin-2-one-1-yl]alkanoic acids

Ronald K Russell,Mary A Appollina,Victor T Bandurco,Donald W Combs,Ramesh M Kanojia,Robert A Mallory,Elizabeth A Malloy,James J Mcnally,Dennis M Mulvey,Yolanda Graynunez,M S Rampulla,Richard A Rampulla,S A Sisk,L Williams,Seymour D Levine,Stanley C Bell,Edward C Giardino,Robert Falotico,Alfonso J Tobia

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY（1992）

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摘要

The synthesis and cardiovascular evaluation of a novel series of [4-alkyl(aryl)quinazolin-2-one-1-yl]alkanoic esters and acids (II) as renal vasodilators is presented. The compound 3-[6.7-dihydroxy-4-methyl-(1H)-quinazoline-2-one-1-yl]propanoic acid (7) was found to be a potent and selective renal vasodilator.

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关键词

QUINAZOLINE-2-ONE,RENAL VASODILATOR,ANTIHYPERTENSIVE

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