Structural requirements for the stability of novel cephalosporins to AmpC β-lactamase based on 3D-structure

Kenji Murano,Toshio Yamanaka,Ayako Toda,Hidenori Ohki,Shinya Okuda,Kohji Kawabata,Kazuo Hatano,Shinobu Takeda,Hisashi Akamatsu,Kenji Itoh,Keiji Misumi,Satoshi Inoue,Tatsuya Takagi

Bioorganic & Medicinal Chemistry（2008）

引用 37|浏览4

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摘要

We propose novel structural requirements that FR259647 derivatives with lower probability of entry into the binding pocket of AmpC β-lactamase are more stable to the enzyme.

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关键词

AmpC β-lactamase,Conformational studies,Cephalosporin,Pseudomonas aeruginosa

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