A Facile Synthesis of Tetrasubstituted 2,3‐dihydrofuran Derivatives Using Poly(ethylene Glycol) As Soluble Support
Journal of heterocyclic chemistry(2010)
摘要
A facile synthesis of tetrasubstitude 2,3-dihydrofurans has been conducted using poly(ethylene glycol) (PEG) as a soluble polymer support. The PEG-supported pyridinium ylides react with 3-arylidene-2,4-pentanedione in the presence of triethylamine (TEA) via conjugate addition to form PEG-supported dihydrofuran derivatives, being cleaved by 1% KCN/EtOH to afford trans-tetrasubstitude-2,3-dihydrofurans, varying from good to excellent yields.
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