4-Anilino-7-pyridyl-3-quinolinecarbonitriles as Src kinase inhibitors.

Nan Zhang,Biqi Wu,Diane H Boschelli,Jennifer M Golas,Frank Boschelli

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

A series of 4-anilino-7-pyridyl-3-quinolinecarbonitriles was prepared as Src kinase inhibitors. The lead compound showed potent activity in both the Src enzyme and cell assays, and demonstrated in vivo anti-tumor activity in a xenograft model.

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4-Anilino-7-pyridyl-3-quinolinecarbonitriles,Src kinase inhibitors

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