Antiapoptotic Function Of Bcl-2 In Mast Cells Is Dependent On Its Association With Heat Shock Protein 90 Beta

BLOOD(2006)

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摘要
In the present study, we demonstrated that the antiapoptotic function of Bcl-2 in mast cells is significantly dependent on its association with the heat shock protein 90 beta (Hsp90 beta). Dissociation of these 2 proteins inhibits the antiapoptotic activity of Bcl-2 by initiating the release of cytochrome c from mitochondria into cytosol and increasing the activity of caspase 3 and caspase 7, resulting in mast-cell apoptosis. The antiapoptotic activity of Bcl-2 was greatly affected by knocking-out specifically Hsp90 beta using the RNA interference approach. Thus, for the first time, it has been shown that Hsp90 beta might modulate the antiapoptotic activity of Bcl-2 at least in mast cells. These findings could have implications for a novel strategy of regulating apoptosis in patients with mastocytosis and other mast cell-associated diseases.
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关键词
heat shock protein
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