N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents.

Gui-Bai Liang,Xiaoxia Qian,Dennis Feng,Michael Fisher,Tami Crumley,Sandra J Darkin-Rattray,Paula M Dulski,Anne Gurnett,Penny Sue Leavitt,Paul A Liberator,Andrew S Misura,Samantha Samaras,Tamas Tamas,Dennis M Schmatz,Matthew Wyvratt,Tesfaye Biftu

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

Diaryl-(4-piperidinyl)-pyrrole derivatives bearing cyclic amine substituents have been synthesized and evaluated as anticoccidial agents. Improvements in potency of Et-PKG inhibition and broad spectrum anticoccidial activities in feed have been achieved.

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关键词

Coccidiosis,PKG,PKG inhibitor

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