Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

Structure–activity relationship studies, focused on the optimization of pharmacology and pharmacokinetics, are described for a series of short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives and calcium-sensing receptor antagonists.

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关键词

Osteoporosis,Human parathyroid hormone,Calcium receptor antagonists,Pharmacokinetics,SAR exploration

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