Identication of Regulation Networks of Lipid Metabolism by Nuclear Receptors

Abstract: IntroductionNuclear receptors form a superfamily of proteins that function as ligand-activated transcription factors.Recently ligands for orphan receptors such as liver X receptor (LXR), farnesoid X receptor(FXR), and peroxisome proliferator-activated receptor (PPAR) have been identified, and they werefound to act as metabolic sensors. Target genes of these nuclear receptors include lipid metabolicenzymes, transporters, and also nuclear receptors themselves, so that these gene products...