1440 EFFECT OF EXERCISE ON PROSTATE CANCER IN THE TRANSGENIC ADENOCARCINOMA OF THE MOUSE PROSTATE (TRAMP) MODEL

You have accessJournal of UrologyProstate Cancer: Basic Research VIII1 Apr 20101440 EFFECT OF EXERCISE ON PROSTATE CANCER IN THE TRANSGENIC ADENOCARCINOMA OF THE MOUSE PROSTATE (TRAMP) MODEL Stephen Strup, Renee Quillin, Hong Pu, Jessica Houtz, Elisabeth Jones, Natasha Kyprianou, and Karyn Esser Stephen StrupStephen Strup More articles by this author , Renee QuillinRenee Quillin More articles by this author , Hong PuHong Pu More articles by this author , Jessica HoutzJessica Houtz More articles by this author , Elisabeth JonesElisabeth Jones More articles by this author , Natasha KyprianouNatasha Kyprianou More articles by this author , and Karyn EsserKaryn Esser More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1133AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Epidemiological evidence indicated a potential inverse relationship between exercise and the risk of developing prostate cancer. In this study we used the transgenic adenocarcinoma of the prostate (TRAMP) mouse model to determine the effect of exercise on survival, tumor development and progression to metastasis. METHODS TRAMP+ (C57BL/6) male mice littermates were placed in two groups: 1. TRAMP+ runners (TPR) and 2. TRAMP+ non-runners (TPNR). TRAMP– males were maintained as controls for running behavior. Mice in the running groups were provided with an exercise wheel which was monitored continuously. The primary endpoints evaluated were survival, primary tumor development and extent, and metastatic burden. Histologic analysis was performed using H & E staining and a standard grading scale for the primary tumors of the TRAMP+ mice. RESULTS The TRAMP+ mice ran, on average, approximately 7km/day which is within the normal running behavior for male C57BL/6 mice. The average age at time of death for the TPR (42.5 +/- 13 weeks) and TPNR (44.2 +/- 11 weeks) was not statistically different. However, the TPNR exhibited larger primary tumor size at the time of death with 71% of the TPNR exhibiting an extensive tumor size in contrast to 25% of the TPR exhibiting extensive tumors. Additionally, TPNR had necrosis in 3/7 primary tumors versus 0/9 primary tumors in TPR. Approximately 40% of the TRAMP+ mice [4/9 runners and 3/7 non-runners] in each group demonstrated metastases. Interestingly, when only those mice with metastases were analyzed, the runners died at an average younger age (41.3 weeks) in contrast to the non-runners (54.3 weeks). CONCLUSIONS Exercise did not alter lifespan of TRAMP+ mice. However, running behavior appeared to impact disease progression. Running was associated with a smaller primary tumor size at death which suggests that running may have an inhibitory effect on primary tumor growth. However, if mice had metastases, there was a trend toward shorter lifespan in the runners versus non-runners. This suggests that if the cancer metastasized, running may facilitate these tumors. Thus, the impact of running on prostate cancer in this transgenic model suggests two potentially independent effects. One is a positive effect by slowing the growth of the primary tumor, while the second effect is more negative and suggests that running may increase the aggressiveness of metastatic disease. Lexington, KY© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e555 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Stephen Strup More articles by this author Renee Quillin More articles by this author Hong Pu More articles by this author Jessica Houtz More articles by this author Elisabeth Jones More articles by this author Natasha Kyprianou More articles by this author Karyn Esser More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...