心力衰竭模型大鼠心脏肥厚指标与心功能的关系研究

Journal of Capital Medical University, pp. 72-75, 2010.

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Abstract:

目的腹主动脉(abdominal aorta,AO)缩窄法建立大鼠慢性心力衰竭模型,比较多项指标在评价心脏肥厚中的意义及其与心功能的关系。方法Wistar大鼠80只,分为手术组和对照组,比较术后第4、8、12和16周B型脑钠肽(type-B natriuretic peptide,BNP)及心脏肥厚指标的变化。结果与对照组相比,大鼠腹主动脉缩窄术后4周,心肌细胞直径(cardiac myocardial diameter,CMD)、心脏重量指数、I型胶原浓度、BNP浓度显著升高(P<0.05)。术后8周-dp/dt降低。术后12周左室收缩末压(LVSP)升高,+dp/dt降低。术后16周上述改变更明显。BNP浓度与血流动力学和心脏肥厚指标相关性良好。结论在腹主动脉缩窄法制...More

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ENThe Relationship between Cardiac Hypertrophy Index and Cardiac Function in Chronic Heart Failure Rats
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