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Pharmacokinetics of methotrexate in the extracellular fluid of brain C6-glioma after intravenous infusion in rats.

Pharmaceutical research, no. 8 (1999): 1219-1225

Cited by: 19|Views2
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Abstract

Establishment of the pharmacokinetic profile of methotrexate (MTX) in the extracellular fluid (ECF) of a brain C6-glioma in rats.Serial collection of plasma samples and ECF dialysates after i.v. infusion of MTX (50 or 100 mg/kg) for 4 h. HPLC assay.Histological studies revealed the presence of inflammation, edema, necrosis, and hemorrhage...More

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