W1972 Both High and Low-Dose Aspirin Inhibits the Growth of Human Esophageal Adenocarcinoma in Nude Mice

overall incidence of CRC of 3.02+/-0.23%. Lower incidences of 1.44+/-0.13% were observed in the 5-ASA treated group, while in the non-5-ASA treated group a significantly higher incidence of 3.23+/-0.45% has been noticed (p<0.05). The risk for CRC was higher in patients with pancolitis in both groups but those from the 5-ASA group has a significantly lower risk with an odds ratio of 0.51 (95% CI, 0.37-0.69) compared with 0.86 (95% CI, 0.71-0.92) for patients which did not followed chemoprevention. Conclusion. Chemopreven- tion with 5-ASA derivatives seems to protect patients with UC from CRC, but the results are influenced by the extension and perhaps the duration of disease.