Cisplatin-Based Chemotherapy In The Management Of Germ Cell Tumors Of The Ovary: The Institut Gustave Roussy Experience
Gynecologic oncology(1997)
摘要
The past two decades have seen great improvements in the diagnosis and management of ovarian germ cell tumors. To assess the impact of cisplatin-based chemotherapy, a retrospective review based on a standardized questionnaire was conducted in 54 patients with malignant germ cell neoplasms of the ovary who received cisplatin-based chemotherapy as part of their first-line or salvage therapy at the Institut Gustave Roussy from September 1980 to December 1992. Chemotherapy was administered as primary postoperative treatment in 40 (75%) patients while 14 patients received chemotherapy as part of their salvage treatment for recurrent disease. With a median follow-up of 6 years, the overall survival is 74%. Twenty-three (96%) of the 24 patients who received chemotherapy in an adjuvant setting are alive without evidence of disease compared to 9 (56%) of 16 and 8 (57%) of 14 who were treated for advanced or recurrent disease, respectively. The long-term toxicity was minimal. Among 22 patients who underwent conservative surgery, 13 resumed normal menstrual function. Four patients delivered 5 healthy children. With male germ-cell tumors as a template, cisplatin-based chemotherapy clearly improves the prognosis for patients with ovarian germ cell tumors, especially in the adjuvant setting. (C) 1997 Academic Press
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