Poly-l-lysine Dissolves Fibrillar Aggregation of the Alzheimer β-Amyloid Peptide in Vitro
Biochemical and Biophysical Research Communications(2002)
摘要
β-Amyloid peptide (βA) is a major fibrillar component of neuritic plaques in Alzheimer's disease (AD) brains and is related to the pathogenesis of the disease. In this study, using electron microscopy, we describe herein the results concerning the efficacy of compounds that can dissolve preformed βA fibrils in vitro. For such a purpose, two hydrosoluble and biocompatible polymers such as polyethylene glycol and poly-l-lysine were used. The poly-l-lysine appears as a potent dissolver of preformed βA fibrils in vitro. Its efficiency is instantaneous. Poly-l-lysine can be used as a universal dissolver of all types of oligomeric β-sheet conformation, precursor of the fibrils. This finding provides the basis for future investigation of the therapeutic potential of poly-l-lysine in terms of preventing and/or retarding amyloidogenesis in AD and other types of amyloid-related disorders.
更多查看译文
关键词
Alzheimer's disease,preformed β-amyloid fibrils,polyethylene glycol,poly-l-lysine,l-lysine
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要