Synthesis of 2-(p-aminobenzyl) derivatives of 1,4,7-triazacyclononane-N,N′,N″-triacetic acid (NOTA) and 1,4,7,10-tetraazacyclododecane-N,N′,N″,N″′-tetraacetic acid (DOTA): macrocyclic bifunctional chelating agents useful for antibodies labeling
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(1993)
摘要
A convenient synthesis of above titled p-aminobenzyl derivatives of NOTA (9) and DOTA (14) are described which is based on a modified Richman-Atkins type macrocyclization between tritosylamide (2) derived from p-nitrophenylalanine, and dimesylates (3) and (4) derived from ethylene glycol and N-toluene-p-sulfonyldiethanolamine, respectively.
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