Influence of naloxone on respiratory mechanics,pulmonary function parameters and oxygen metabolism in patients with chronic obstructive pulmonary disease and respiratory failure

Objective:To study the influence of naloxone on respiratory mechanics,pulmonary function parameters and oxygen metabolism in patients with chronic obstructive pulmonary disease and respiratory failure.Methods:A total of 27 patients with chronic obstructive pulmonary disease and respiratory failure who were treated with routine treatment in our hospital from July 2010 to June 2012 were selected as control group,and 27 patients who were treated with routine treatment and naloxone at the same time were selected as observation group,then the respiratory mechanics,pulmonary function parameters and oxygen metabolism indexes of two groups were compared before and 3,5 days after the treatment were detected and compared.Results:After 3 and 5 days of treatment,the improvement in respiratory mechanics,pulmonary function parameters and oxygen metabolism indexes were more obvious than that of control group,and those indexes of observation group 5 days after the treatment were all better than those at third day(P all0.05=all showing significant differences.Conclusion:Naloxone produced favor influence on respiratory mechanics,pulmonary function parameters and oxygen metabolism of patients with chronic obstructive pulmonary disease and respiratory failure,and it can significantly improve the general state of body.