Identification of novel glycine sulfonamide antagonists for the EP1 receptor

Stephen C. McKeown,Adrian Hall,Richard Blunt,Susan H. Brown,Iain P. Chessell,Anita Chowdhury,Gerard M.P. Giblin,Mark P. Healy,Matthew R. Johnson,Olivier Lorthioir,Anton D. Michel,Alan Naylor,Xiao Lewell,Shilina Roman,Stephen P. Watson,Wendy J. Winchester,Richard J. Wilson

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

The discovery, synthesis, pharmacokinetic profile and structure–activity relationships of a novel series of non-acidic EP1 receptor antagonists are described.

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关键词

EP1 antagonist,Pain,Pyrazole,Prostanoid

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