The use of antibody and complement to gain access to the interior of presynaptic nerve terminals
Experimental Brain Research(1980)
摘要
Treatment of synaptosomes with sera containing antibodies (Ab) directed against synaptosomal membranes and complement (C) alters the plasma membrane so that it becomes selectively permeable to small molecules and ions but not to proteins. When synaptosomes are incubated with Ab and C, a rapid release of intracellular K occurs. This release does not occur after treatment with antiserum alone, or with normal serum + C. Ab + C treatment releases approximately the same amount of K as does detergent treatment or hypotonic lysis, two procedures that extensively disrupt the plasma membrane.
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关键词
Synaptosomes,Antibodies,Complement,Membrane permeability,Intracellular environment
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