Protection Of Guinea-Pigs Against Foot-And-Mouth-Disease Virus By Immunization With A Phoe Fmdv Hybrid Protein

M Agterberg,H Adriaanse,S Barteling,K van Maanen, J Tommassen

VACCINE（1990）

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摘要

A hybrid protein was constructed containing two antigenic determinants of the structural protein VP1 of foot-and-mouth disease virus, inserted in a cell surface-exposed region of Escherichia coli outer membrane protein PhoE. Immunization of guinea-pigs with partially purified protein resulted in high levels of neutralizing antibodies and complete protection against challenge with the virus.

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关键词

foot-and-mouth disease virus,phoe protein,carrier system,vaccine,biotechnology

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