Non Thiazolidinedione Antihyperglycaemic Agents .1. Alpha-Heteroatom Substituted Beta-Phenylpropanoic Acids

D.R. Buckle,B.C.C. Cantello,M.A. Cawthorne,P.J. Coyle,D.K. Dean,A. Faller,D. Haigh,R.M. Hindley,L.J. Jefcott,C.A. Lister,I.L. Pinto,H.K. Rami,D.G. Smith,S.A. Smith

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1996）

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摘要

The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents can be replaced by a range of alpha-heteroatom functionalised beta-phenylpropanoic acids. alpha-Oxy-carboxylic acids show potent antidiabetic activity and one compound, the alpha-ethoxyacid 15 (SE 213068), is one of the mast potent antihyperglycaemic agents yet reported. Copyright (C) 1996 Elsevier Science Ltd

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non thiazolidinedione antihyperglycaemic agents

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