Growth hormone treatment does not alter lower limb asymmetry in children with Russell-Silver syndrome.

Background: Growth hormone (GH) treatment has been proven to have a beneficial effect on growth in children with Russell-Silver syndrome (RSS). Methods: We describe 7 prepubertal children with RSS and lower limb asymmetry treated with GH for 3 years. Results: There was a significant increase in height without any significant change in the asymmetry. Conclusions:We conclude that the rapid growth acceleration to GH treatment does not alter the lower limb asymmetry in children with RSS. Copyright (C) 2002 S. Karger AG, Basel.