Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies

Cell biochemistry and biophysics, Volume 60, Issue 3, 2011, Pages 173-185.

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Keywords:
aggresome inclusion bodies proteasome inhibitor ubiquitin-proteasome system misfoldedubiquitinationproteinsubiquitin proteasome systemcell lineMore(6+)

Abstract:

Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous fluorescence-based assay was devised to detect aggregated proteins inside aggresomes and inclusion bodies within an authentic cellular contex...More

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