Vibrateur NH et activité antitumorale des cyclophosphazènes vectorisés par des polyamines biogènes

A comparative i.r. spectroscopic study of NH groups in natural polyamines both free and covalently bound to antitumor cyclophosphazenes allows one to explain the remarkable selectivity towards malignant cells of such drugs when vectorized through such polyamines as tumor finders and to classify the targeting potentiality of these polyamines as a function of the various configurations they adopt when linked to the cyclophosphazenic antitumor agents.