Cyclobutane-containing peptides: evaluation as novel metallocarboxypeptidase inhibitors and modelling of their mode of action.

Daniel Fernández,Elisabeth Torres,Francesc X Avilés,Rosa M Ortuño,Josep Vendrell

Bioorganic & Medicinal Chemistry（2009）

引用 57|浏览6

暂无评分

摘要

Among other peptides evaluated, these compounds were active and selective. Aromatic stacking plays an important role in the binding to the active sited of the target enzymes.

查看译文

关键词

Metalloprotease,Inhibitor screening,Ligand docking,Human carboxypeptidase B,Cyclobutane β-peptide,Non-natural amino acid

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要