Synthesis and vitro antibacterial activity of hygromycin a analogs modified at the C4′ aryl position
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(1993)
摘要
A variety of hygromycin A analogs are described which contain modifications of or replacements for the natural sugar. Antibacterial activities against Serpulina (Treponema) hyodysenteriae, an important animal health pathogen, are reported and indicate that small lipophilic C4' substituents serve as useful sugar surrogates in the hygromycin A class.
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