Parallel Synthesis Of 1,2,4-Oxadiazoles Using Cdi Activation

Tracy L Deegan,Theodore J Nitz,Diane Cebzanov,Denise E Pufko,John A Porco

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1999）

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摘要

1,2,4-Oxadiazoles have been prepared in parallel using 1,1'-carbonyldiimidazole (CDI) as a reagent for both formation and cyclodehydration of O-acyl benzamidoximes. The use of CDI facilitates parallel purification of the oxadiazole products by simple liquid-liquid extraction and filtration. (C) 1999 Elsevier Science Ltd. All rights reserved.

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