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Determining selectivity of drugs by quantitative two-dimensional gel analysis

BIOCHEMICAL PHARMACOLOGY, no. 6 (1996): 917-925

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Abstract

In vitro pharmacologic measures of drug specificity are well established, i.e, drug interaction with a specific target such as an enzyme, receptor, or ion channel. However, in vitro measures of drug selectivity, defined as effects on secondary targets, are lacking. Two-dimensional gel electrophoresis (2-D gel) was examined as a measure of...More

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