Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase

David A. Scott,Carrie L. Balliet,Donald J. Cook,Audrey M. Davies,Thomas W. Gero,Charles A. Omer,Srinivasu Poondru,Maria-Elena Theoclitou,Boris Tyurin,Michael J. Zinda

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

3-Amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modifications at the quinoline 6- and 7-positions.

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关键词

CSF-1R,Kinase inhibitor,Quinoline

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