Separation of enantiomers by supercritical fluid extraction

The purpose of the present study is to demonstrate the applicability of SFE for the separation of enantiomeric acid mixtures. (±)-cis- and (±)-trans-permetric acids were resolved with R-(+)-α-phenylethylamine and S-(+)-2-benzylaminobutan-1-ol, respectively. The effects of temperature and pressure on the quantity and quality of cis- and trans-acid resolution products are demonstrated. Partial resolutions of the acids were investigated in the range 100–200bar and 33–47°C by designed experiments.