P53/miR-34a/SIRT1 positive feedback loop regulates the termination of liver regeneration

Junhua Gong,Minghua Cong,Hao Wu,Menghao Wang,He Bai,Jingyuan Wang,Keting Que,Kaiwen Zheng,Wenfeng Zhang,Xiaoli Yang,Jianping Gong,Hanping Shi,Mingyong Miao,Fangchao Yuan

Aging（2023）

引用 30|浏览14

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摘要

The P53/miR-34a/SIRT1 positive feedback loop plays an important role in the termination of LR. Our findings showed the molecular and metabolic mechanisms of LR termination and provide a potential therapeutic alternative for treating P53-wild-type HCC patients.

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关键词

HCC,P53,SIRT1,liver regeneration,miR-34a

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