Surface-induced hydrogelation inhibits platelet aggregation
Journal of the American Chemical Society, Volume 135, Issue 1, 2013, Pages 266-271.
We demonstrate that a tripeptide hydrogelator, Nap-FFG, can selectively self-assemble at the surface of platelets, thus inhibiting ADP-, collagen-, thrombin- and arachidonic acid (AA)-induced human platelet aggregations with the IC(50) values of 0.035 (41), 0.14 (162), 0.062 (68), and 0.13 mg/mL (148 μM), respectively. Other tripeptide hy...More
Full Text (Upload PDF)
PPT (Upload PPT)