Surface-induced hydrogelation inhibits platelet aggregation

Journal of the American Chemical Society, Volume 135, Issue 1, 2013, Pages 266-271.

Cited by: 44|Bibtex|Views15|DOI:https://doi.org/10.1021/ja308690y
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Other Links: pubmed.ncbi.nlm.nih.gov|academic.microsoft.com

Abstract:

We demonstrate that a tripeptide hydrogelator, Nap-FFG, can selectively self-assemble at the surface of platelets, thus inhibiting ADP-, collagen-, thrombin- and arachidonic acid (AA)-induced human platelet aggregations with the IC(50) values of 0.035 (41), 0.14 (162), 0.062 (68), and 0.13 mg/mL (148 μM), respectively. Other tripeptide hy...More

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