A synthetic steroid 5α-androst-3β,5,6β-triol blocks hypoxia/reoxygenation-induced neuronal injuries via protection of mitochondrial function.

Jiesi Chen,Tiandong Leng,Wenli Chen,Min Yan,Wei Yin,Yijun Huang,Suizhen Lin,Dayue Duan,Jun Lin,Gongxiong Wu,Jingxia Zhang,Guangmei Yan

Steroids（2013）

引用 14|浏览12

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摘要

•5α-Androst-3β,5,6β-triol was synthesized by 3 steps starting from DHEA.•5α-Androst-3β,5,6β-triol is neuroprotective against hypoxia/reoxygenation exposure.•The mechanism of action involves protection of mitochondrial function.

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关键词

5α-Androst-3β,5,6β-triol,Hypoxia/reoxygenation,Neuroprotection,Mitochondrial function,Oxidative stress

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