Chemical constituents of the stems of Celastrus rugosus

Two new sesquiterpene pyridine alkaloids rugosusines A and B ( 1 and 2 ), and thirty-one known compounds were isolated from the stems of Celastrus rugosus . The structures of new compounds were elucidated by detailed spectroscopic analysis, including HR-ESI–MS and 2D NMR spectroscopic data. All the compounds were isolated from this plant for the first time. The cytotoxicities of these compounds were tested against SKOV3 and MGC-803 cell lines by CCK-8 method.