Tailored Design And Synthesis Of Heparan Sulfate Oligosaccharide Analogues Using Sequential One-Pot Multienzyme Systems

Heparan sulfate analogues: Highly efficient one-pot multienzyme (OPME) chemoenzymatic systems for the activation and transfer of N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA) have been developed. They were applied to the sequential tailored synthesis of N-sulfated analogues of heparan sulfate oligosaccharides, which could be potential therapeutics. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.