Non-invasive measurement of haemodynamic changes with a multi-wavelength NIRS system
Journal of Computational Information Systems(2013)
摘要
Near Infrared Spectroscopy (NIRS) can be employed to monitor noninvasively, continuously and timely local changes in haemodynamics and oxygenation of human tissues. The study of spatial variations of tissue oxygenation, specifically: oxy-haemoglobin (HbO2); deoxy-haemoglobin (HHb); and total haemoglobin (Hbtot) would provide the opportunity to evaluate the responses of the peripheral circulation to physiological challenges. We describe the design of apparatus based on low cost optical components, with light-emitting diodes (LED) as the light sources and sensitive photodiodes (PD) as the detectors. Changes in chromophore concentration were calculated using the modified Lambert-Beer Law and diffusion theory. We use four wavelengths, 735 nm, 760 nm, 810 nm and 850 nm. Source-detector spacing was varied to derive blood oxygen changes at different depths. Using multiple source-detector spacing, the spatial distribution of these changes could be visualized in the response curve. Forearm occlusion experiments demonstrated changes in oxygenation in agreement with theory. In a liquid tissue phantom changes in HbO2, HHb and blood volume were followed faithfully with the NIRS instrument. Overall, the results of this investigation demonstrate the usefulness of the multi-wavelength NIRS instrument for deriving haemodynamic information from biological tissues. © 2013 by Binary Information Press.
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关键词
Blood volume,Lambert-beer law,Near infrared spectroscopy,Spatial measurement,Tissue oxygenation
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