Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats

Shao-Qiu He,Fei Yang, Federico M. Perez,Qian Xu,Ronen Shechter,Yong-Kwan Cheong,Alene F. Carteret,Xinzhong Dong,Sarah M. Sweitzer,Srinivasa N. Raja,Yun Guan

PAIN®（2013）

引用 18|浏览25

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摘要

This study suggests that animals with neuropathic pain develop acute tolerance to the antiallodynic effects of peripherally acting opioids after repetitive systemic and local drug administration.

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关键词

Nerve injury,Neuropathic pain,Peripheral opioid receptor,Rats,Tolerance

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