PI3-kinase is essential for ADP-stimulated integrin α IIbβ3-mediated platelet calcium oscillation, implications for P2Y receptor pathways in integrin αIIbβ 3-initiated signaling cross-talks

Journal of Biomedical Science, Volume 12, Issue 6, 2005, Pages 937-948.

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Keywords:
ADPCalcium oscillationIntegrin αIIbβ3P2Y receptorsPhosphatidylinositol 3-kinase

Abstract:

Phosphatidylinositol 3-kinase (PI3K) pathway is important for platelet activation. Recent studies showed that PI3K and oscillative calcium could cross talk to each other and positively regulate integrin α IIbβ 3-mediated outside-in signaling. However, the mechanism of this feedback regulation remains to be further characterized. Here we f...More

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