Comparative genomic analysis of genogroup 1 (Wa-like) rotaviruses circulating in the USA, 2006-2009.
Infection, Genetics and Evolution(2014)
摘要
•We report the genome sequences of 33 group A human rotaviruses collected in USA 2006–2009.•The strains included 16 G1P[8], 10 G3P[8], and 7 G9P[8].•All 33 strains had a Wa like backbone with the consensus genotype constellation of G(1/3/9)-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1.•For the G3 and G9 strains, we identified 3–7 allelic constellations grouped by VP7 genotypes suggesting allelic segregation.•Vaccine failure strains showed similar grouping for all G9 strain genes and most genes of G3 strains.
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关键词
Rotavirus,Vaccine,Failure,Allele,VP4,VP7
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