RAD51AP1-deficiency in vertebrate cells impairs DNA replication.

Ann C Parplys,Katja Kratz,Michael C Speed,Stanley G Leung,David Schild,Claudia Wiese

DNA Repair（2014）

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摘要

•We report on the phenotype of RAD51AP1-deficient DT40 cells.•RAD51AP1 is required for the resolution of DNA damage-induced RAD51 foci.•RAD51AP1 is required for the maintenance of DNA replication fork progression.•RAD51AP1-deficient DT40 cells show increased firing of dormant replication origins.•RAD51AP1 may also function by transducing DNA damage signals.

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关键词

Homologous recombination,DNA replication,RAD51 foci,RAD51AP1,DT40 cells

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